Paget's disease PD of the breast is a rare disease. However, most women with Paget's disease who don't have a lump have non-invasive cancer. The role of angiogenesis, as determined by MVD, has been examined in vulval lichen sclerosus, vulval intraepithelial neoplasia VIN , and vulval cancer [ 29 — 31 ]. However, HER2 is a better marker of Paget disease because the underlying carcinoma is often a high-grade ductal carcinoma in situ with comedonecrosis, which is generally ER negative and HER2 positive. MPD is sometimes difficult to diagnose both clinically and radiologically, therefore it is important to distinguish from other conditions:
On staining with hematoxylin and eosin, these cells typically show pale cytoplasm, eccentric and hyperchromatic nuclei and are called as Paget cells which are found throughout the epidermis [ 6 ]. The concept that Paget cells are in fact malignant keratinocytes, which has been transformed in situ, has been put forward as the transformation theory [ 8 ]. Paget disease of the nipple: J Am Coll Surg ; Late Effects of Childhood Cancer Treatment. This theory would explain the small number of people who: The outcome of biopsy dictates the best choice of surgical option.
Paget Disease of the Breast - National Cancer Institute
In advanced cases, the process may extend from the nipple to the pigmented skin of the areolar region and even to the adjacent surrounding, nonpigmented skin of the breast. Mammary and extramammary Paget's disease. Ultrasonography did not reveal any lump. Ann Surg Oncol ;4: It is supported by the predominance of breast cancer markers found in Paget's disease. Nevertheless, underlying ductal breast cancer is often confined to the central, subareolar part of the breast.
The rate of multifocal disease was 7. Paget disease of the breast is a cutaneous manifestation of underlying breast malignancy. Breast conserving treatment of Paget's disease. Cancer Types Locations Site Menu. Design by Rangoli Creations.